BackgroundColon adenocarcinoma (COAD) is the most frequently occurring type of colon cancer.Cancer-associated fibroblasts (CAFs) are pivotal in facilitating tumor growth and metastasis; however, their specific role in COAD is not yet fully understood.This research utilizes single-cell RNA sequencing (scRNA-seq) to identify and validate gene markers
The Motion Decoupled Oils Hydraulic Delivery System (MDHDS) is a new downhole tool delivery system that is deployed by wireline and uses drillstring pressure to advance a penetrometer (or other downhole tool) into the formation at the bottom of offshore boreholes.After hydraulic deployment of the penetrometer, it is completely decoupled from the BH
Immobilization of load-bearing bones results in imbalance of bone turnover followed by bone loss and impairment of its mechanical function.The question is whether immobilization induced bone loss is accompanied by deterioration of properties of the bone tissue components.Thermally induced transformations of collagen reflect the overall condition of
Cystic fibrosis (CF) is a genetic disease hallmarked by aberrant ion transport that results in delayed mucus clearance, chronic infection, and progressive lung function decline.Several animal models have been developed to study the airway anatomy and mucus physiology in CF, but they are costly and difficult to maintain, making them less accessible